Anwendungen

Die parallele Peptidsynthese ist der produktivste Weg zu gewünschten Wirkstoff-Bibliotheken. Viele Tausend Literaturstellen mit stark zunehmender Tendenz berichten von den Möglichkeiten dieser Technologie.

MultiPep 2

SPOT Synthesen im MultiPep 2

Chen, Z. et al. 2020. Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12. Open Biol. 10: 200041.

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Lam, F. W. et al., 2020. The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium. PloS one, Public Library of Science San Francisco, CA USA, 15, e0240164.

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Louros, N. et al., 2020. WALTZ-DB 2.0: an updated database containing structural information of experimentally determined amyloid-forming peptides. Nucleic acids research, Oxford University Press, 48, D389-D393.

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Mertens, C. et al., 2020. Stereo controlled, multi-functional sequence-defined oligomers through automated synthesis. Polymer Chemistry, Royal Society of Chemistry, 11, 4271-4280.

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Suwatthanarak, T. et al., 2020. Screening and characterisation of CdTe/CdS quantum dot-binding peptides for material surface functionalisation. RSC Advances, Royal Society of Chemistry, 10, 8218-8223.

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Teng, F. et al., 2020. Identification of continuous immunoglobulin G epitopes of Dermatophagoides farinae allergens by peptide microarray immunoassay. IUBMB life, Wiley Online Library, 72, 1976-1985.

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Chandra, D. et al., 2019. Design of peptide ligands for affinity purification of human growth hormone. Journal of Chemical Technology & Biotechnology, Wiley Online Library, 94, 2345-2354

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Chen, Z. et al., 2019. Structural basis for recruitment of DAPK1 to the KLHL20 E3 ligase. Structure, Elsevier, 27, 1395-1404.

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Collins, R. A. 2019. Exploration into the MLL4/WRAD enzyme-substrate network: Systematic identification of CFP1 as a non-histone substrate of the MLL4 lysine methyltransferase. Carleton University, Carleton University. de Castro, K. L. P. et al., 2019. A combined strategy to improve the development of a coral antivenom against Micrurus spp. Frontiers in immunology, Frontiers, 10, 2422.

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Guedes, D. C., et al., ,2019. Biological evaluation of mimetic peptides as active molecules for a new and simple skin test in an animal model. Parasitology research, Springer, 118, 317-324

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Lambert, J.-P. et al. 2019. Interactome rewiring following pharmacological targeting of BET bromodomains. Molecular cell, Elsevier, 73, 621-638

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Liu, H. et al. 2019. Surface loops in a single SH2 domain are capable of encoding the spectrum of specificity of the SH2 family. Molecular & Cellular Proteomics, Band 18, pp. 372-382.

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Ma, L. et al. 2019. Establishing a detection method for CCNY: a potentially significant clinical investigative marker in NSCLC patients. OncoTargets and therapy, Dove Press, 12, 921

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Mardirossian, M. et al., 2019. Proline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii. ChemMedChem, Wiley-Blackwell, 14, 2025

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Rasmussen, M. S. et al.2019. Use of peptide arrays for identification and characterization of LIR motifs. Autophagy, Springer, 2019, 149-161

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Shastry, D. G. et al., 2019. Microarrays for the screening and identification of carbohydrate-binding peptides. Analyst, Royal Society of Chemistry, 144, 7378-7389

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Skånland, S. S. et al., 2019. Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signalling. The Journal of Immunology, Am Assoc Immnol, 203, 1055-1063

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Sutton, M. N. et al., 2019. DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1. Cancers, Band 11, p. 557.

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von Gundlach, A.; et al. 2019. BioSAXS measurements reveal that two antimicrobial peptides induce similar molecular changes in gram-negative and gram-positive bacteria.

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Wirth, M. et al., 2019. Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins. Nature communications, Band 10, p. 2055.

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CelluSPOT Synthesen und Slides im MultiPep 2

Katz C. et al. (2011) Studying protein-protein interactions using peptide arrays. Chem. Soc. Rev. 2011; 40: 2131-2145

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Schulte C. et al., (2020). High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale. iScience 24, 101898, January 22, 2021, this is an open access article under the CC BY license

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Peptid-Arrays im MultiPep

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

This work describes the discovery of pre-existing binding and neutralising antibodies against SARS-CoV-2 in uninfected and unexposed individuals. These antibodies, likely induced by exposure to seasonal coronaviruses, are present in a small percent of adults but in the majority of children, consistent with the relative sparing of the latter from the severe form of COVID-19. In this study the Peptide Chemistry STP used our expertise and experience to firstly synthesise a set of peptide arrays to screen antibodies and following on from the array experiments, we synthesised a set of peptides for ELISA studies.

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